ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. The smallest units, the elementary fibrils (cellulose crystalline strands) are made up of many -(1-4) glucose chains which are bundled to form microfibrils. Your file is uploaded and ready to be published. Request media, explore upcoming events and read our latest updates. Product Name: Microcrystalline Cellulose E460 1.2. Home. No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . /Contents 4 0 R With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . : 160182. X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. (AEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEM %)piQpFNnFu\4m4( ESE;m& %QL((((((((((((((((((((((((((((((((((((((((P3NhC Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. endobj Safety Data Sheet for Cellulose microcrystalline 102331. Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. SUBSTANCE IDENTIFICATION 1.1. 1 0 obj The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. Avicel PC 611 (FMC Biopolymer) . The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. Packaging: 34 x 50 kgs fiber drums. Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . Microcrystalline Cellulose / Avicel PH-102. CAS 9004-34-6. In 1964 FMC, Corporation . In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. 5 0 obj Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> FMC, JRS and Mingtai were estimated to hold for . Go to Investor Relations. In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. Avicel PC 611 Microcrystalline Cellulose. MSDS Ref. Microcrystalline Cellulose Side Effects. F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W It is a white, free-flowing powder. 130. <> %PDF-1.5 Micro Crystalline Cellulose. Battista, O. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. %PDF-1.4 Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. Alginates from IFF are an excellent choice for consistent performance in a variety of applications. endobj This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication. Millipore. We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. Safety Data Sheet (SDS) Viewer. It is generally regarded as a relatively nontoxic and non-irritant material that is safe for human and animal consumption. 1 0 obj G2W4de=u183KGH{ vQ#4:1\wc 2008-2023 ChemPoint. Report Category. The typical mean particle size is 20200 m. B;vLZpHU%ChUyD+[ 4. Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Avicel Microcrystalline Cellulose: Chemical Identifiers. Alubra is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures. % Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. stream CAS #: 9004-34-6 1.6. 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. Have an order or account question, find answers in our Online Support articles. These, in turn, are assembled into fibrils in the cell wall. Revision No. Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. Performing this action will revert the following features to their default settings: Hooray! JFIF ` ` ZExif MM * J Q Q Q C gwf;J(e0o|1p{R~P^);ao!%{0KD7. P}MFbN#[>r(y !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[ Microcrystalline Cellulose. PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. This Microcrystalline Cellulose . Microcrystalline Cellulose / Avicel PH-102. q9;v80 EINECS #: 232-674-9 1.7. Synergies to simplify formulation challenges and reduce operational costs. Generally, these can be classified into two broad groups: Standard grades, and Co-processed grades. Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . !(!0*21/*.-4;K@48G9-.BYBGNPTUT3? Watch Now. Earth Supplied Products LLC. <> MATERIAL SAFETY DATA SHEET Version: 1.0 1. Production of Pharmaceutical Grade Microcrystalline Cellulose. CAS #: 9004-34-6 . GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. Remove Avicel co-processed grades are co-spray dried blends of Avicel microcrystalline cellulose with synergistic pharmaceutical excipients to yield functional benefits beyond simple physical blends. Eur., JPE . Find answers in our support articles. . This extends the funcionality of microcrystalline cellulose to meet specific viscosity, gelling, suspension and stabilizing properties ChemPoint is an approved supplier of LATTICE MCC in industrial applications, providing dedicated marketing, sales, order fulfillment, and technical support for customers in the EMEA region, Protect and improve AI potency, entrap oil droplets and improve stability, physical barrier that helps suspend particles and breaks down under shear and reforms quickly under rest. Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. 2 0 obj Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. CAS 9004-34-6, pH 5 - 7.5. Microcrystalline Cellulose NF. Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. Well-recognized product that can do it all. Cellulose microcrystalline. "l%I-*j|-)@ EtG[TQd%8,.fg4QqH'-dV ?3Z#GK# dGnF7x*3yY\VUwPhmyYT@f67Zcsmdi!%94K@:L# vJeU-kzRT-(YX/fKC Validity Area. CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. Product Name: Microcrystalline Cellulose 1.2. Magazine: Material safety data sheet - FMC Corporation. Product Name Cellulose microcrystalline. Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. Document(s): certificate data msds. 4 0 obj In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. /PRNewswire/ -- ReportsnReports added Global Microcrystalline Cellulose (MCC) Market Growth 2019-2024 to its online research database. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose . In large quantities it provides dietary bulk and may lead to a laxative effect. 0.25 - 0.37. 1. We can send by Fedex, by ship or by plane according to international rules. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. q86@on$^X_HuH;3` IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. : 51395-75-6 Date Approved: 01/31/2008 Revision No. Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. The figure below illustrates the structural organisation of cellulose within plants. ETHOCEL premium ethylcellulose resins are water-insoluble polymers. Van Veen, G.K. Bolhuis, Y.S. gac74 [#B6`Wnw7 Origin(s): Plant/Botanical. }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e ^Q-{@ RPC t/(If>8P&%wNPMJw,VI2aUqRqe3bC,a;C&4RQSf*(=I$r{'%jmk1LUZV(*is6r&wQPAAoID4p?,"lp:wE+)v(_w 'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. Avicel PC 611 (FMC Biopolymer) Supplied by. No. Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. YUMPU automatically turns print PDFs into web optimized ePapers that Google loves. The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. All Rights Reserved. HMo@9, U Q!R/1*;` Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. Powder becomes slippery when wet. The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. Explore how we work and why we apply science and creativity for a better world to everything we do. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Material Name: Estradiol Tablets Trade Name: RONFASE . No. Apply today! Biologicals by FMC. Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. Thus, Avicel contributes no or very few calories to the food system. If you are already a ChemPoint customer then sign up for access to our online ordering website. Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . /MediaBox [0 0 612 792] %PDF-1.3 stream iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. undefined. Manufactured by: China . INCI. Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. Heavy metals, % NMT 0.001 However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? PDF (28.38 mb) 2022 Corporate Fact Sheet. %PDF-1.4 1 0 obj However, if handling bulk powders, observance of appropriate safeguards is recommended. Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) endobj Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. We are artists at heart and creators by nature. Avicel Microcrystalline cellulose occurs as a white, odourless, tasteless, fibrous powder composed of porous particles. Test Data Available. 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. POLYOX resins are nonionic polyethylene oxide solubility polymers. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. Avicel Microcrystalline Cellulose Physical Properties. To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O << The aqueous solution to barrier membrane coating. Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. The product would later go on to be commercialized under the brand name Avicel by FMC Corporation. . The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. Alginates also function as actives in some anti-reflux products. %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz 102331. FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? The most. Watch Now. Meet our leadership team. Catalog Number 102331. The data shown below apply only to Avicel PH 101. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. % TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. Regulatory Information Terms and Conditions Compliance Solutions Industries About 3E News & Events . This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication MCC helps in the formation of spheres because of its . Molecular weight: Not Applicable 1.5. By producing Avicel . stream It works as a moisture sponge and permits the controlled growth of spheroids. Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. However, consumption of large quantities of the material may have a laxative effect. Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. Wu, K. Zuurman, H.W. BIOACCUMULATIVE POTENTIAL Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. : 1. More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. It is, however, a good source of fibre. All rights reserved. They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more. /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) MSDS Ref. Avicel RC-591 offers ideal thixotropic bahavior for stabilizing suspensions while Avicel CL-611 is a stabilizer for reconstitutable or dry suspension formulations. pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q c Dh)#t'kTfIZT1-_y"+wXj,qo!~ozc}ZemZ``$'vj{, Ga;]2iY*DIh~F3Z!.pkL:bHHBTbIcw9.Xo$4,?On4s=R,KLz /M|#PF(j%j oF2[5 ,rx)bd1$LM4Dc-d\@W D?A?L/7>s]-};Z if^+e3}AeQ# U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. q9;v80q>jZ Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. endobj endstream \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN!